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Model 2400 Patch Clamp Amplifier


Model 2400 Patch Clamp Amplifier

Model 2400 Patch Clamp Amplifier, 110 V, 60 Hz


Catalog: #88000

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Price: $3,125.00 

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Summary

The Model 2400 is a low-noise, full-featured intracellular/extracellular amplifier designed for voltage clamping using patch electrodes on single channels or whole cells. Its unique design allows fast intracellular current clamp measurements with sharp electrodes. Advanced circuit design techniques using field programmable gate arrays eliminated noisy microprocessors.
  • Full-Function Patch Clamp Amplifier for both whole cells and patches
  • True Current Clamp is 100% stable with bandwidth of 200kHz.
  • Switchable Dual Resistive Feedback Headstage
  • Capacity, series resistance, and whole cell compensation
  • 4-pole Low-Pass Bessel Filters
  • Internally generated test signals
  • Telegraph outputs for all major front panel controls
  • Independent hold, offset, and tracking circuitry
  • Displays command potentials, cell currents, and voltages
Amplifier current gain is extremely flexible as it can accept any of four resistive feedback probes. Each probe has two feedback resistors selected from the following values: 10 MΩ, 50 MΩ, 100 MΩ, 1 GΩ, 5 GΩ, and 10 GΩ. The wide range of feedback resistors means currents can be recorded with outputs of 1 mV/nA to 10 mV/fA. The standard probe sent with each unit is the 100 MΩ/10 GΩ version, but other values can be selected.

Unlike other patch clamp amplifiers, the Model 2400 has a voltage follower in the probe. This allows this amplifier to be a true fast current clamp amplifier with no instability. An integrated four pole low pass Bessel filter provides flexible signal conditioning. Fine tuning capacity compensation is available to eliminate virtually all electrode-induced transients. Calibrated whole cell compensation provide easy display of membrane capacitance and access resistance.

A host of command potentials are integrated internally within the model 2400, including an automatic tracking command to zero the membrane current, manual controls for offset and holding potentials, and an easily readable digital display. For signals that are more complicated, an external command input with different scaling factors is available for use with any signal source.

A digital meter provides accurate values of command signals and membrane currents or voltages, the true RMS noise of the amplifier and experimental setup, the cut off frequency of the low pass filter, and the overall gain of the amplifier plus probe.

Series resistance compensation provides the researcher with the option of introducing either or both predictive and corrective compensation from zero to 100%. Fine and coarse controls for lag provide sensitive control to minimize oscillation produced by compensation close to 100%.

Separate compensation controls exist for eliminating transients seen during current clamp experiments when the bridge balance is used.

Telegraph outputs provide analog voltage equivalents of front panel settings including error conditions, amplifier mode and gain, Cmembrane, RMS noise, and low pass filter cut-off value. These telegraphs allow the Model 2400's front panel settings to be automatically recorded by your system software.

For those who need extra large bandwidths, the raw bandwidth of the entire amplifier may be adjusted via a rear panel potentiometer.

A second powered probe input is available for use as a bath signal input.


Description

Probe Gain and Bandwidth

Feedback Resistor Probe Gain Maximum Current Minimum Bandwidth
10 MΩ 10 mV/nA 1000 nA 100 kHz
100 MΩ 100 mV/nA 100 nA 100 kHz
1 GΩ 1 mV/pA 10 nA 60 kHz
10 GΩ 10 mV/pA 1 nA 40 kHz

Probe Case Size
  • 2.1" (54mm) long x 0.8"(20mm) high x 1.4"(36mm) wide
  • BNC input connector
  • 1 mm ground pin connector
Maximum Instrument Noise

Voltage clamp modes measured with the internal 4 pole Bessel filter and minimum external noise.

Headstage Resistor (Ωs)
Bandwidth 10 M 100 M 1 G 10 G
1 kHz Theoretical Limit 0.002 nA 0.4 pA 0.1 pA 0.04 pA
1 kHz 0.003 nA 0.5 pA 0.17 pA 0.08 pA
Current clamp modes have noise levels less than 20 µV with inputs shorted.

Internal Bandwidth
For voltage clamping only the bandwidth is settable from 10 kHz to 100 kHz.

Membrane Current Output Range

Probe Feedback Resistor Output Range
10 MΩ 10 mV/nA-1 V/nA
100 MΩ 100 mV/nA-10 V/nA
1 GΩ 1 mV/pA-100 nV/pA
10 GΩ 10 mV/pA-1 V/pA

Membrane Voltage Output Range
  • 10 mV/mV-1 V/mV
Filter
  • 4 pole Bessel filter with 6 pre-set values, and bypass: 0.5 kHz, 1.0 kHz, 2.0 kHz, 5.0 kHz, 10.0 kHz, and 20.0 kHz.
  • 0.1 kHz resolution
Capacity Compensation
  • Voltage clamp:
    • FAST1: 0-10 pF, 0.2-2 µs
    • FAST2: 0-1 pF, 0.1-10 ms
  • Current clamp
    • FAST1: 0-10 pF
    • No FAST2
Whole Cell Compensation
  • Raccess: 0-100 MΩ
  • Cmembrane: 0-100 pF
Series Resistance
  • RsPre: 0-100%
  • RsComp: 0-100%
  • LagCoarse: 1-100 µs
  • LagFine: 1-10 µs
DC Balance
  • Up to the value of the low feedback resistor in the probe
Hold Command
  • Voltage clamp: ±200 mV
  • Current clamp:
Probe Resistor 10 M 100 M
Command Range ±200 nA ±20 nA

Offset Command
  • Voltage clamp: ±100 mV
  • Current clamp: ±1 V
Speed Test Command
  • Used in voltage clamp only.
  • Probe High Gain: 0.2 nA p-p at 60 Hz
  • Probe Low Gain: 1 nA p-p at 60 Hz
Vcomp Command
  • ±5 mV at 60 Hz
Iresist Command
  • ±1 nA at 60 Hz
External Command
  • Voltage clamp: 100 mV/V with the external switch set to 410, 20 mV/V with the external switch set to 450
  • Current clamp:
Probe Resistor 10 M 100 M
410 range ±100 nA/V ±10 nA/V
450 range ±20 nA/V ±2 nA/V




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Extended Warranty, 2 Year, Model 2400 with headstage
Extended Warranty, 2 Year, Model 2400 with headstage
$250.00
     



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