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Neuroprobe Amplifier Model 1600

The Model 1600 includes:

  • Operator's manual
  • Rack mount hardware

Note: For proper operation, the purchase of a Model 1600-compatible headstage (Catalog#: 681500) is required. A Model 1600 headstage will be automatically added when you add a Model 1600 Amplifier to cart.

Please note that A-M Systems instruments are not approved for use with human subjects in either a clinical or research environment.

Catalog # Description Price Quantity
680100 Model 1600 Neuroprobe Amplifier (AC Power) 110 V, 60 Hz $1,989.00 
Quantity:
680105 Model 1600 Neuroprobe Amplifier (AC Power) 220 V, 50 Hz $1,989.00 
Quantity:
681500 Model 1600 Headstage $295.00 
Quantity:
682000 Model 6820 Iontophoresis Adapter $250.00 
Quantity:
749916 Extended Warranty, 2 Year, Model 1600 with headstage $225.00 
Quantity: 



Summary

The Neuroprobe Amplifier Model 1600 is a precision-crafted microelectrode amplifier designed especially for the exacting requirements of intracellular neurological studies. It is a self-contained unit with many built-in features that reduce the need for additional instrumentation and provides the research scientist with versatility, accuracy and ease of operation. The Digital Panel Meter produces a highly accurate display of membrane potential, injected current or electrode resistance. 

The internal Dual-Function Transient Control and the DC balance Control assure extremely precise recordings during current injection without requiring an external bridge or a differential input oscilloscope. The ten-turn potentiometers used for the DC Offset, DC balance, Current Injection, and dual Capacitance Compensation Controls allow high resolution. And internal square-wave generator supplies 100 Hz current to test electrode resistance and to adjust capacitance compensation, with the resistance values directly displayed on the Digital Panel Meter.

The Neuroprobe Amplifier's advanced current injection system, adjustable to 0.1 nA resolution, allows external switching of both internal and external current sources. The total current from all sources can be displayed on the Digital Panel Meter prior to injection. This capability allows the user to inject the exact amount of current desired. Depending upon the requirements of the experiment, the user can also select either momentary or continuous injection. The Model 1600 has been carefully engineered to eliminate noise that might adversely affect test results.

The Neuroprobe Amplifier can be used with computer equipment or a standard chart recorder to generate a permanent record of injected current and neurological response. It has a direct input for use as a Digital Volt Meter and is also adaptable as a general purpose electrometer, with outputs displayed on the Digital Panel Meter.

This Iontophoresis Adapter allows the researcher to apply higher voltages to the micropipette for iontophoretic injection of drugs or dyes, or any other application where currents greater than those provided by the Neuroprobe Amplifier are required.

Specifications

Current Input
  • Impedance: 1011 Ω
  • Capacitance: Adjustable to zero
  • Working Range: ± 2.5 V
  • Maximum Range: ± 10 V
  • Iontophoresis Adapter Input: ± 200 V
Current Injection: External Source
  • Input Impedance: 20 kΩ
  • Frequency Range: DC to 250 kHz
  • Low Range Maximum Current: 10 nA/V
  • Low Range Maximum Voltage: lesser of ± 10V and (± 2.5 x 108 VΩ)/(electrode resistance)
  • High Range Maximum Current: 100 nA/V
  • High Range Maximum Voltage: lesser of ± 10V and (± 2.5 x 107 VΩ)/(electrode resistance)
Current Injection: External Source
  • Low Range Maximum Current: lesser of ± 100 nA and 2.5 V/(electrode resistance)
  • Low Range Maximum Voltage: lesser of ± 1000 nA and 2.5 V/(electrode resistance)
Current Gate
  • ON Signal: + 2.5 V (Step with rise time 10 µsec)
  • OFF Signal: +0.6 V
  • Maximum Input: ± 15 V
  • Input Impedance 20 kΩ
Electrode Test: External Signal Source
  • Input Impedance: 10 kΩ
  • Input Voltage Range: ± 10 V
  • Low Range Scale Factor (x1 Output): 1 mV/MΩ/(input voltage)
  • High Range Scale Factor (x1 Output): 10 mV/MΩ/(input voltage)
Electrode Test: Internal Signal Source
  • Signal: 100 Hz Square Wave
  • Low Range Scale Factor (x1 Output): 1 nA p-p produces 1 mV/MΩ
  • High Range Scale Factor (x1 Output): 10 nA p-p produces 1 mV/MΩ
Signal Processing: Input Bias Current
  • Optimal: Adjustable to Zero
  • Maximum without adjustment, Low Range: 3x10-12 Amp
  • Maximum without adjustment, High Range: 3x10-11 Amp
  • Drift vs Temperature, Low Range: 1x10-13 Amp/°C
  • Drift vs Temperature, High Range: 1x10-12 Amp/°C
  • Drift vs Time, Low Range: 3x10-13 Amp/12 hours
  • Drift vs Time, High Range: 3x10-12 Amp/12 hours
Signal Processing: Frequency Response
  • Frequency Range: DC to 325 kHz
Signal Processing: Rise Time
  • Square Wave (500 mV) 50 Ω Source: 0.8 µsec (10% to 90%)
  • Square Wave (500 mV) 20 MΩ Source: 7.0µsec (10% to 90%)
Signal Processing: Zero Stability
  • Stability vs Temperature: 200 µV/°C
  • Stability vs Time:1 mV/12 hours
Signal Processing: Low Pass Filter
  • Cut-off Frequencies (-3 dB): 1, 2, 5, 10, 20, 50, 100 kHz
  • Slope: -12 dB/octave 
Signal Processing: Notch Filter
  • Center Frequency: 50 Hz or 60 Hz (factory preset)
  • Q: 10
  • Rejection: -50 dB
Signal Processing: Capacitance Compensation
  • Range: -4 pF to +30 pF
Signal Processing: Internal Calibration Voltage
  • 10mV: ± 1%
  • 1000mV: ± 1%
Signal Processing: Noise
  • 0 Ω Source: 13 µV RMS (10Hz to 50kHz)
  • 1 MΩ Source: 79 µV RMS (10Hz to 50kHz)
  • 20 MΩ Source: 310 µV RMS (10Hz to 50kHz)
Signal Processing: DC Balance
  • Low Range: up to 500 MΩ
  • High Range: up to 50 MΩ
Output x1
  • Voltage Gain: 1.00 ± 0.1%
  • Maximum Voltage: ± 10V
  • Impedance: 220 Ω
  • DC Offset Range: 0.0 V to ± 1.0 V
Output x10
  • Voltage Gain: 10.00 ± 1.0%
  • Maximum Voltage: ± 10 V
  • Impedance: 220 Ω
  • DC Offset Range: 0.0 V to ± 10.0 V
Output: Current Monitor
  • Low Range Scale Factor: 10 mV/nA
  • High Range Scale Facto: 1 mV/nA
  • Maximum Output: ± 1.0 V
  • Output Impedance: 1 kΩ

FAQ

The following is a list of commonly asked questions regarding this product. If you have any additional questions, please feel free to contact us at 800-426-1306 for further information.

  • Can I get a replacement Instruction Manual for this instrument?
  • Is it possible to have a Model 1600 amplifier customized for my preferred gain and filter settings?
  • Do you sell extension cables for your headstages?
  • My Model 1600 is not working, but our university has an excellent electronics facility. Can we repair the unit ourselves?
  • Can I use this instrument outside of the United States?
  • What are the proper operating and storage conditions for my Model 1600?
  • Can I get a replacement Instruction Manual for this instrument?

    Additional Operator's Manuals are available for download by clicking on the 'Downloads' section from the menu bar at the top of this web page.

    Is it possible to have a Model 1600 amplifier customized for my preferred gain and filter settings?

    Yes, in most circumstances, we can easily customize at our factory any of our amplifiers' filter and/or gain settings. Please contact technical support (800-426-1306, or tech@a-msystems.com for more information.

    Do you sell extension cables for your headstages?

    We do not sell extensions, however we do sell new headstages with longer cables (for a small customization charge). The maximum length is usually 12 feet. Typically, the main amplifier needs to be returned to us for calibration with the new longer headstage cables.

    My Model 1600 is not working, but our university has an excellent electronics facility. Can we repair the unit ourselves?

    It is recommended that A-M Systems perform the needed repairs as we are the most familiar with the units. However, if you are confident in your electronic technician's skills, you can always purchase the schematics for the Model 1600 from us (Cat#683000) and attempt them yourself. Please note that any user-attempted repairs during the warranty period may invalidate the warranty, and might invoke additional charges to correct them if A-M Systems is required to make repairs at a later date.

    Can I use this instrument outside of the United States?

    All of A-M Systems instruments can be modified to work outside of the United States. Typically, this modification is made at the factory (at no additional cost) prior to shipping to our customers. Just inform the customer service department where the instrument will be used, so our technicians can prepare the proper power supply modifications.

    What are the proper operating and storage conditions for my Model 1600?

    The Model 1600 is designed to be used under laboratory conditions. Operate in a clean, dry environment only. Do not operate in a damp environment. Temperatures for storage and operation should be between 5 °C and 40 °C. Storage should be indoors in a cool dry place.

    Headstage

    The Head Stage for the Neuroprobe Amplifier is designed to assure the user flexibility in application as well as optimum recordings.  It can be mounted in a standard micromanipulator, and its small size (0.44" diameter; 4" long) insures its adaptability to various experimental conditions.  The mounting rod can be attached either to the end of the head stage for a vertical experimental configuration or to the mounting adapter for a right-angle configuration.  The head stage has a standard 0.08" pin connector jack for use with half-cell microelectrode holders.

    The head stage features an internal driven shield to be placed around the body of the electrode from reduced capacitance and noise.  It houses a wide bandwidth, FET-input operational amplifier and current injection and capacitance compensation components.  The input impedance is typically 1014 Ohms; the input current is typically less than 1.0 pA; the bandwidth is greater than 325 kHz.

    All metal parts are chrome-plated to resist corrosion. The flexible 5' cable is silicone jacketed to resist mild alkalis, acids and solvents.

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